RT Journal Article
SR Electronic
T1 Bmp8a Is a Novel Player in Regulation of Antiviral Immunity
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.08.09.243519
DO 10.1101/2020.08.09.243519
A1 Zhong, Shenjie
A1 Li, Haoyi
A1 Wang, Yun-Sheng
A1 Wang, Ying
A1 Ji, Guangdong
A1 Li, Hong-Yan
A1 Zhang, Shicui
A1 Liu, Zhenhui
YR 2020
UL http://biorxiv.org/content/early/2020/09/10/2020.08.09.243519.abstract
AB Bone morphogenetic protein (BMP) is a kind of classical multi-functional growth factor that plays a vital role in the formation and maintenance of bone, cartilage, muscle, blood vessels, and the regulation of energy balance. Whether BMP plays a role in antiviral immunity is unknown. Here we demonstrate that Bmp8a is a newly-identified positive regulator for antiviral immune responses. The bmp8a−/− zebrafish, when infected with the viruses of GCRV, SVCV or TSVDV, show significantly reduced antiviral immunity, increased viral load and morbidity. We also show for the first time that Bmp8a interacts with Alk6a, which promotes the phosphorylation of Tbk1 and Irf3 through p38 MAPK pathway, and induces the production of type I IFNs in response to virus infection. Upon virus infection, bmp8a expression is activated through the binding of Stat1a/Stat1b to the GAS motifs in bmp8a promoter region, enlarging the antiviral innate immune signal. Our study uncovers a previously unrecognized role of Bmp8a in regulation of antiviral immune responses and provides a new target for controlling viral infection.Competing Interest StatementThe work is under a patent in China: A method to improve the antiviral immunity of fish (Application No.201910454499.6).