PT  - JOURNAL ARTICLE
AU  - Pickering, Brad S.
AU  - Smith, Greg
AU  - Pinette, Mathieu M.
AU  - Embury-Hyatt, Carissa
AU  - Moffat, Estella
AU  - Marszal, Peter
AU  - Lewis, Charles E.
TI  - Susceptibility of domestic swine to experimental infection with SARS-CoV-2
AID  - 10.1101/2020.09.10.288548
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.09.10.288548
4099  - http://biorxiv.org/content/early/2020/09/10/2020.09.10.288548.short
4100  - http://biorxiv.org/content/early/2020/09/10/2020.09.10.288548.full
AB  - SARS-CoV-2, the agent responsible for COVID-19 has been shown to infect a number of species. The role of domestic livestock and the risk associated for humans in close contact remains unknown for many production animals. Determination of the susceptibility of pigs to SARS-CoV-2 is critical towards a One Health approach to manage the potential risk of zoonotic transmission. Here, pigs undergoing experimental inoculation are susceptible to SARS-CoV-2 at low levels. Viral RNA was detected in group oral fluids and nasal wash from at least two animals while live virus was isolated from a pig. Further, antibodies could be detected in two animals at 11 and 13 days post infection, while oral fluid samples at 6 days post inoculation indicated the presence of secreted antibodies. These data highlight the need for additional livestock assessment to better determine the potential role domestic animals may contribute towards the SARS-CoV-2 pandemic.Competing Interest StatementThe authors have declared no competing interest.