RT Journal Article
SR Electronic
T1 Susceptibility of domestic swine to experimental infection with SARS-CoV-2
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.10.288548
DO 10.1101/2020.09.10.288548
A1 Pickering, Brad S.
A1 Smith, Greg
A1 Pinette, Mathieu M.
A1 Embury-Hyatt, Carissa
A1 Moffat, Estella
A1 Marszal, Peter
A1 Lewis, Charles E.
YR 2020
UL http://biorxiv.org/content/early/2020/09/10/2020.09.10.288548.abstract
AB SARS-CoV-2, the agent responsible for COVID-19 has been shown to infect a number of species. The role of domestic livestock and the risk associated for humans in close contact remains unknown for many production animals. Determination of the susceptibility of pigs to SARS-CoV-2 is critical towards a One Health approach to manage the potential risk of zoonotic transmission. Here, pigs undergoing experimental inoculation are susceptible to SARS-CoV-2 at low levels. Viral RNA was detected in group oral fluids and nasal wash from at least two animals while live virus was isolated from a pig. Further, antibodies could be detected in two animals at 11 and 13 days post infection, while oral fluid samples at 6 days post inoculation indicated the presence of secreted antibodies. These data highlight the need for additional livestock assessment to better determine the potential role domestic animals may contribute towards the SARS-CoV-2 pandemic.Competing Interest StatementThe authors have declared no competing interest.