PT  - JOURNAL ARTICLE
AU  - Rishi Rajalingham
AU  - Michael Sorenson
AU  - Reza Azadi
AU  - Simon Bohn
AU  - James J DiCarlo
AU  - Arash Afraz
TI  - Chronically implantable LED arrays for behavioral optogenetics in primates
AID  - 10.1101/2020.09.10.291583
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.09.10.291583
4099  - http://biorxiv.org/content/early/2020/09/11/2020.09.10.291583.short
4100  - http://biorxiv.org/content/early/2020/09/11/2020.09.10.291583.full
AB  - Challenges in behavioral optogenetics in large brains demand development of a chronically implantable platform for light delivery. We have developed Opto-Array, a chronically implantable array of LEDs for high-throughput optogenetic perturbation in non-human primates. We tested the Opto-Array in the primary visual cortex of a macaque monkey, and demonstrated that optogenetic cortical silencing by the Opto-Array results in reliable retinotopic visual deficits on a luminance discrimination task.Competing Interest StatementM.S. is a principal engineer at Blackrock Microsystems (Utah).