PT  - JOURNAL ARTICLE
AU  - Gao, Xiaofei
AU  - Li, Jun-Liszt
AU  - Chen, Xingjun
AU  - Ci, Bo
AU  - Chen, Fei
AU  - Lu, Nannan
AU  - Shen, Bo
AU  - Zheng, Lijun
AU  - Jia, Jie-Min
AU  - Yi, Yating
AU  - Zhang, Shiwen
AU  - Shi, Ying-Chao
AU  - Shi, Kaibin
AU  - Propson, Nicholas E
AU  - Huang, Yubin
AU  - Poinsatte, Katherine
AU  - Zhang, Zhaohuan
AU  - Yue, Yuanlei
AU  - Bosco, Dale B
AU  - Lu, Ying-mei
AU  - Yang, Shi-bing
AU  - Adams, Ralf H.
AU  - Lindner, Volkhard
AU  - Huang, Fen
AU  - Wu, Long-Jun
AU  - Zheng, Hui
AU  - Han, Feng
AU  - Hippenmeyer, Simon
AU  - Stowe, Ann M.
AU  - Peng, Bo
AU  - Margeta, Marta
AU  - Wang, Xiaoqun
AU  - Liu, Qiang
AU  - Körbelin, Jakob
AU  - Trepel, Martin
AU  - Lu, Hui
AU  - Zhou, Bo O.
AU  - Zhao, Hu
AU  - Su, Wenzhi
AU  - Bachoo, Robert M.
AU  - Ge, Woo-ping
TI  - Reduction of neuronal activity mediated by blood-vessel regression in the brain
AID  - 10.1101/2020.09.15.262782
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.09.15.262782
4099  - http://biorxiv.org/content/early/2020/09/15/2020.09.15.262782.short
4100  - http://biorxiv.org/content/early/2020/09/15/2020.09.15.262782.full
AB  - The brain vasculature supplies neurons with glucose and oxygen, but little is known about how vascular plasticity contributes to brain function. Using longitudinal in vivo imaging, we reported that a substantial proportion of blood vessels in the adult brain sporadically occluded and regressed. Their regression proceeded through sequential stages of blood-flow occlusion, endothelial cell collapse, relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels were found to be widespread in mouse, monkey and human brains. Both brief occlusions of the middle cerebral artery and lipopolysaccharide-mediated inflammation induced an increase of vessel regression. Blockage of leukocyte adhesion to endothelial cells alleviated LPS-induced vessel regression. We further revealed that blood vessel regression caused a reduction of neuronal activity due to a dysfunction in mitochondrial metabolism and glutamate production. Our results elucidate the mechanism of vessel regression and its role in neuronal function in the adult brain.Competing Interest StatementThe authors have declared no competing interest.