TY - JOUR T1 - Evolving super stimuli for real neurons using deep generative networks JF - bioRxiv DO - 10.1101/516484 SP - 516484 AU - Carlos R. Ponce AU - Will Xiao AU - Peter F. Schade AU - Till S. Hartmann AU - Gabriel Kreiman AU - Margaret S. Livingstone Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/01/17/516484.abstract N2 - Finding the best stimulus for a neuron is challenging because it is impossible to test all possible stimuli. Here we used a vast, unbiased, and diverse hypothesis space encoded by a generative deep neural network model to investigate neuronal selectivity in inferotemporal cortex without making any assumptions about natural features or categories. A genetic algorithm, guided by neuronal responses, searched this space for optimal stimuli. Evolved synthetic images evoked higher firing rates than even the best natural images and revealed diagnostic features, independently of category or feature selection. This approach provides a way to investigate neural selectivity in any modality that can be represented by a neural network and challenges our understanding of neural coding in visual cortex.A generative deep neural network interacted with a genetic algorithm to evolve stimuli that maximized the firing of neurons in alert macaque inferotemporal and primary visual cortex.The evolved images activated neurons more strongly than did thousands of natural images.Distance in image space from the evolved images predicted responses of neurons to novel images. ER -