RT Journal Article
SR Electronic
T1 Inference of recent admixture using genotype data
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.16.300640
DO 10.1101/2020.09.16.300640
A1 Peter Pfaffelhuber
A1 Elisabeth Sester-Huss
A1 Franz Baumdicker
A1 Jana Naue
A1 Sabine Lutz-Bonengel
A1 Fabian Staubach
YR 2020
UL http://biorxiv.org/content/early/2020/09/18/2020.09.16.300640.abstract
AB The inference of biogeographic ancestry (BGA) has become a focus of forensic genetics. Mis-inference of BGA can have profound unwanted consequences for investigations and society. We show that recent admixture can lead to misclassification and erroneous inference of ancestry proportions, using state of the art analysis tools with (i) simulations, (ii) 1000 genomes project data, and (iii) two individuals analyzed using the ForenSeq DNA Signature Prep Kit. Subsequently, we extend existing tools for estimation of individual ancestry (IA) by allowing for different IA in both parents, leading to estimates of parental individual ancestry (PIA), and a statistical test for recent admixture. Estimation of PIA outperforms IA in most scenarios of recent admixture. Furthermore, additional information about parental ancestry can be acquired with PIA that may guide casework.Competing Interest StatementThe authors have declared no competing interest.