RT Journal Article
SR Electronic
T1 Enhancing synergy of CAR T cell therapy and oncolytic virus therapy for pancreatic cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 055988
DO 10.1101/055988
A1 Rachel Walker
A1 Pedro E. Navas
A1 Samuel H. Friedman
A1 Simona Galliani
A1 Aleksandra Karolak
A1 Fiona Macfarlane
A1 Robert Noble
A1 Jan Poleszczuk
A1 Shonagh Russell
A1 Katarzyna A. Rejniak
A1 Amir Shahmoradi
A1 Frederik Ziebell
A1 Jason Brayer
A1 Daniel Abate-Daga
A1 Heiko Enderling
YR 2016
UL http://biorxiv.org/content/early/2016/05/30/055988.abstract
AB The poor immunogenicity of pancreatic tumors makes them particularly difficult to treat. Standard chemotherapies and single agent immunotherapies have had notoriously little success in this arena. Oncolytic virus therapy has the potential to enhance the penetration of immunotherapeutically-delivered CAR T cells into the tumor and improve treatment outcomes. We evaluate this potential by combining two different mathematical approaches: an ordinary differential equation model to simulate population level tumor response to cytotoxic activity of T cells, coupled with an agent-based model to simulate the enhancement of CAR T cell penetration by oncolytic virus therapy.