RT Journal Article
SR Electronic
T1 The Dual Mechanisms of Cognitive Control (DMCC) Project
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.18.304402
DO 10.1101/2020.09.18.304402
A1 Todd S. Braver
A1 Alexander Kizhner
A1 Rongxiang Tang
A1 Michael C. Freund
A1 Joset A. Etzel
YR 2020
UL http://biorxiv.org/content/early/2020/09/20/2020.09.18.304402.abstract
AB The Dual Mechanisms of Cognitive Control (DMCC) project provides an ambitious and rigorous empirical test of a theoretical framework that posits two key cognitive control modes: proactive and reactive. The framework’s central tenets are that proactive and reactive control reflect domain-general dimensions of individual variation, with distinctive neural signatures, involving lateral prefrontal cortex (PFC) in interactions with other brain networks and circuits (e.g., frontoparietal, cingulo-opercular). In the DMCC project, each participant is scanned while performing theoretically-targeted variants of multiple well-established cognitive control tasks (Stroop, Cued Task-Switching, AX-CPT, Sternberg Working Memory) in three separate imaging sessions, that each encourage utilization of different control modes, plus also completes an extensive out-of-scanner individual differences battery. Additional key features of the project include a high spatio-temporal resolution (multiband) acquisition protocol, and a sample that includes a substantial subset of monozygotic twin pairs and participants recruited from the Human Connectome Project. Although data collection is still continuing (target N=200), we provide an overview of the study design and protocol, planned analytic approaches and methodological development, along with initial results (N=80) revealing novel evidence of a domain-general neural signature of reactive control. In the interests of scientific community building, the dataset will be made public at project completion, so it can serve as a valuable resource.Competing Interest StatementThe authors have declared no competing interest.