TY - JOUR T1 - DISPOT: A simple knowledge-based protein domain interaction statistical potential JF - bioRxiv DO - 10.1101/525535 SP - 525535 AU - Oleksandr Narykov AU - Dmitry Korkin Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/01/20/525535.abstract N2 - Motivation The complexity of protein-protein interactions (PPIs) is further compounded by the fact that an average protein consists of two or more domains, structurally and evolutionary independent subunits. Experimental studies have demonstrated that an interaction between a pair of proteins is not carried out by all domains constituting each protein, but rather by a select subset. However, finding which domains from each protein mediate the corresponding PPI is a challenging task.Results Here, we present Domain Interaction Statistical POTential (DISPOT), a simple knowledge-based statistical potential that estimates the propensity of an interaction between a pair of protein domains, given their SCOP family annotations. The statistical potential is derived based on the analysis of more than 352,000 structurally resolved protein-protein interactions obtained from DOMMINO, a comprehensive database on structurally resolved macromolecular interactionsAvailability and implementation DISPOT is implemented in Python 2.7 and packaged as an open-source tool. DISPOT is implemented in two modes, basic and auto-extraction. The source code for both modes is available on Github: (https://github.com/KorkinLab/DISPOT) and standalone docker images on DockerHub: (https://cloud.docker.com/u/korkinlab/repository/docker/korkinlab/dispot). ER -