RT Journal Article
SR Electronic
T1 Placental effects on maternal brain revealed by disrupted placental gene expression in mouse hybrids
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 527143
DO 10.1101/527143
A1 Lena Arévalo
A1 Polly Campbell
YR 2019
UL http://biorxiv.org/content/early/2019/01/22/527143.abstract
AB The mammalian placenta is both the physical interface between mother and fetus, and the source of endocrine signals that target the maternal hypothalamus, priming females for parturition, lactation and motherhood. Despite the importance of this connection, the effects of altered placental signaling on the maternal brain are understudied. Here, we show that placental dysfunction alters gene expression in the maternal brain, with the potential to affect maternal behavior. Using a cross between the house mouse and the Algerian mouse in which hybrid placental development is abnormal, we sequenced late gestation placental and maternal medial preoptic area transcriptomes and quantified differential expression and placenta-maternal brain co-expression between normal and hybrid pregnancies. The expression of Fmn1, Drd3, Caln1 and Ctsr was significantly altered in the brains of females exposed to hybrid placentas. Most strikingly, expression patterns of placenta-specific gene families and Drd3 in the brains of house mouse females carrying hybrid litters matched those of female Algerian mice, the paternal species in the cross. Our results indicate that the paternally-derived placental genome can influence the expression of maternal-fetal communication genes, including placental hormones, revealing a previously unrecognized effect of the offspring's father on the mother's brain.