RT Journal Article
SR Electronic
T1 Game theoretic methods in population dynamics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 056341
DO 10.1101/056341
A1 David Liao
YR 2016
UL http://biorxiv.org/content/early/2016/05/31/056341.abstract
AB Game theoretic methods are used to model the dynamics of cellular populations (tissues) in which it is necessary to account for changes in cellular phenotype (usually proliferation) resulting from cell-cell interaction. Results include prediction of long-term steady-state “equilibria” and transient dynamics. These results can be useful for predicting relapse after cytoreduction, assessing the efficacy of alternating combination therapy, and interpreting biopsy specimens obtained from spatially heterogeneous tissues. Mathematical tools range from simple systems of differential equations to computational techniques (individual-based models).