TY - JOUR T1 - TMS-evoked EEG potentials from prefrontal and parietal cortex: reliability, site specificity, and effects of NMDA receptor blockade JF - bioRxiv DO - 10.1101/480111 SP - 480111 AU - Nigel C. Rogasch AU - Carl Zipser AU - Ghazaleh Darmani AU - Tuomas P. Mutanen AU - Mana Biabani AU - Christoph Zrenner AU - Debora Desideri AU - Paolo Belardinelli AU - Florian Müller-Dahlhaus AU - Ulf Ziemann Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/01/22/480111.abstract N2 - Measuring the brain’s response to transcranial magnetic stimulation (TMS) with electroencephalography (EEG) offers a unique insight into the local cortical circuits and networks activated following stimulation, particularly in non-motor regions where less is known about TMS physiology. However, the mechanisms underlying TMS-evoked EEG potentials (TEPs) remain largely unknown. We assessed TEP reliability, site-specificity, and sensitivity to changes in excitatory neurotransmission mediated by n-methyl-d-aspartate (NMDA) receptors following stimulation of non-motor regions. In fourteen male volunteers, resting EEG and TEPs from prefrontal (PFC) and parietal (PAR) cortex were measured before and after administration of either dextromethorphan (an NMDA receptor antagonist) or placebo across two sessions separated by at least a week in a double-blinded pseudo-randomised crossover design. At baseline, TEPs showed lower within-than between-subject variability for both stimulation sites across sessions, demonstrating the reliability of non-motor TEPs within individuals. There were differences in amplitude between PFC and PAR TEPs across a wide time range (15-250 ms), however the signals were correlated after ~80 ms, suggesting that early peaks reflect site-specific activity, whereas late peaks reflect activity patterns less dependent on the stimulated sites. TEPs were not altered following dextromethorphan compared to placebo, however low frequency resting oscillations were reduced in power. Our findings suggest that TEPs from PFC and PAR: 1) are reliable within and variable between individuals; 2) reflect stimulation site specific activity across early time periods (<80 ms); and 3) are not sensitive to changes in NMDA receptor-mediated neurotransmission. ER -