RT Journal Article
SR Electronic
T1 Brain Abnormalities Associated with Self-Injurious Thoughts and Behaviors: A Meta-Analysis of Neuroimaging Studies
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 526525
DO 10.1101/526525
A1 Huang, Xieyining
A1 Rootes-Murdy, Kelly
A1 Bastidas, Diana M.
A1 Nee, Derek E.
A1 Franklin, Joseph C.
YR 2019
UL http://biorxiv.org/content/early/2019/01/23/526525.abstract
AB Self-injurious thoughts and behaviors (SITBs) have long been believed to result in part from brain abnormalities. This meta-analysis aims to evaluate whether the extant literature justifies any definitive conclusions about whether and how SITBs may be associated with aberrant findings. Sixty studies published through June 1st, 2017 that compared individuals with and without SITBs were included, resulting in 734 coordinates. A pooled meta-analysis assessing for general risk for SITBs indicated a lack of convergence on structural abnormalities. Functional abnormalities in the precuneus/posterior cingulate cortex (PCC), temporal-parietal junction, and rostral-lateral prefrontal cortex were significant using multi-level kernel density analysis but nonsignificant using activation-likelihood estimation. Separate analyses for types of SITBs suggested that deliberate self-harm might be associated with abnormalities in the precuneus/PCC. Some moderator effects were detected. Overall, the meta-analytic evidence was not robust. More studies are needed to reach definitive conclusions about whether SITBs are associated with brain abnormalities.