PT  - JOURNAL ARTICLE
AU  - Matthew C Altman
AU  - Darawan Rinchai
AU  - Nicole Baldwin
AU  - Elizabeth Whalen
AU  - Mathieu Garand
AU  - Basirudeen Ahamed Kabeer
AU  - Mohammed Toufiq
AU  - Scott Presnell
AU  - Laurent Chiche
AU  - Noemie Jourde-Chiche
AU  - J Theodore Phillips
AU  - Goran Klintmalm
AU  - Anne O’Garra
AU  - Matthew Berry
AU  - Chloe Bloom
AU  - Robert J Wilkinson
AU  - Christine M Graham
AU  - Marc Lipman
AU  - Ganjana Lertmemongkolchai
AU  - Davide Bedognetti
AU  - Farrah Kheradmand
AU  - Asuncion Mejias
AU  - Octavio Ramilo
AU  - Karolina Palucka
AU  - Virginia Pascual
AU  - Jacques Banchereau
AU  - Damien Chaussabel
TI  - A Novel Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Sixteen Disease and Physiological States
AID  - 10.1101/525709
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 525709
4099  - http://biorxiv.org/content/early/2019/01/23/525709.short
4100  - http://biorxiv.org/content/early/2019/01/23/525709.full
AB  - Blood transcriptomics measures the abundance of circulating leukocyte RNA on a genome-wide scale. Dimension reduction is an important analytic step which condenses the number of variables and permits to enhance the robustness of data analyses and functional interpretation. An approach consisting in the construction of modular repertoires based on differential co-expression observed across multiple biological states of a given system has been described before. In this report, a new blood transcriptome modular repertoire is presented based on an expended range of disease and physiological states (16 in total, encompassing 985 unique transcriptome profiles). The input datasets have been deposited in NCBI public repository, GEO. The composition of the set of 382 modules constituting the repertoire is shared, along with extensive functional annotations and a custom fingerprint visualization scheme. Finally, the similarities and differences between the blood transcriptome profiles of this wide range of biological states are presented and discussed.BIIRBaylor Institute for Immunology ResearchCOPDChronic Obstructive Pulmonary DiseaseDAVIDDatabase for Annotation Visualization and Integrated DiscoveryFCFold ChangeFDRFalse Discovery RateGO_BPGene Ontology Biologic ProcessGO_MFGene Ontology Molecular FunctionHIVHuman Immunodeficiency VirusIFNInterferonIRBInstitutional Review BoardKEGGKyoto Encyclopedia of Genes and GenomesMSMultiple SclerosisPCRPolymerase Chain ReactionPIDPrimary Immune DeficiencyROCReceiver Operating CharacteristicRSVRespiratory Syncytial VirusSLESystemic Lupus ErythematosusSOJIASystemic onset Juvenile Idiopathic ArthritisTBTuberculosisTBDTo Be Determined