%0 Journal Article %A Ananda Kishore Mukherjee %A Shalu Sharma %A Parashar Dhapola %A Dhurjhoti Saha %A Tabish Hussain %A Sumitabho Deb Roy %A Gunjan Purohit %A Anirban Kar %A Ankita Singh %A Suman Sengupta %A Vivek Srivastava %A Manish Kumar %A Sagar Sengupta %A Shantanu Chowdhury %T Transcriptional activity of TRF2 is telomere length dependent %D 2016 %R 10.1101/056481 %J bioRxiv %P 056481 %X TRF2 is a telomere repeat binding factor crucial for telomere maintenance and genome stability. An emerging non-conventional role of TRF2 is as a transcriptional regulator through extra-telomeric bindings. Herein we report that increase in telomere length leads to sequestration of TRF2 at the telomeres leading to reduced extra-telomeric TRF2 occupancy genome wide. Decrease in TRF2 occupancy was found on multiple gene promoters in cells with elongated telomeres, including the cell cycle regulator kinase-p21. We found that TRF2 is a transcriptional repressor of p21, and, interestingly, TRF2-mediated regulatory control of p21 is telomere length dependent. %U https://www.biorxiv.org/content/biorxiv/early/2016/06/01/056481.full.pdf