RT Journal Article
SR Electronic
T1 The natural axis of transmitter receptor distribution in the human cerebral cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.28.316646
DO 10.1101/2020.09.28.316646
A1 Goulas, Alexandros
A1 Changeux, Jean-Pierre
A1 Wagstyl, Konrad
A1 Amunts, Katrin
A1 Palomero-Gallagher, Nicola
A1 Hilgetag, Claus C
YR 2020
UL http://biorxiv.org/content/early/2020/09/29/2020.09.28.316646.abstract
AB Transmitter receptors constitute a key component of the molecular machinery for inter-cellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distil these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization, and a sensory-to-association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density), excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor density) and mirrored, orderly changes of the density of ionotropic and metabotropic receptors. The uncovered natural axis formed by the distribution of receptors aligns with the axis that is formed by other dimensions of cortical organization, such as the myelo- and cytoarchitectonic levels. Therefore, the uncovered natural axis constitutes a unifying organizational feature linking multiple dimensions of the cerebral cortex, thus bringing order to the heterogeneity of cortical organization.Competing Interest StatementThe authors have declared no competing interest.