RT Journal Article
SR Electronic
T1 Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 307009
DO 10.1101/307009
A1 Rafiq Huda
A1 Grayson O. Sipe
A1 Vincent Breton-Provencher
A1 K. Guadalupe Cruz
A1 Gerald N. Pho
A1 Elie Adam
A1 Liadan M. Gunter
A1 Austin Sullins
A1 Ian R. Wickersham
A1 Mriganka Sur
YR 2020
UL http://biorxiv.org/content/early/2020/09/29/307009.abstract
AB Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Top-down modulation by the prefrontal cortex (PFC) is thought to be key for both processes but the precise role of specific circuits remains unclear. We examined the sensorimotor function of anatomically distinct outputs from a subdivision of the mouse PFC, the anterior cingulate cortex (ACC). Using a visually guided two-choice behavioral paradigm with multiple cue-response mappings, we dissociated the sensory and motor response components of sensorimotor control. Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate specific motor responses. Importantly, ACC outputs exert top-down control by reducing the innate response bias of the superior colliculus. In contrast, ACC outputs to the visual cortex facilitate sensory processing of visual cues. Our results ascribe motor and sensory roles to ACC projections to the superior colliculus and the visual cortex and demonstrate for the first time a circuit motif for PFC function wherein anatomically non-overlapping output pathways coordinate complementary but distinct aspects of visual sensorimotor behavior.Competing Interest StatementThe authors have declared no competing interest.