RT Journal Article
SR Electronic
T1 Phase-Amplitude Coupling of Neural Oscillations can be Effectively Probed with Concurrent TMS-EEG
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 273482
DO 10.1101/273482
A1 Sarah Glim
A1 Yuka O. Okazaki
A1 Yumi Nakagawa
A1 Yuji Mizuno
A1 Takashi Hanakawa
A1 Keiichi Kitajo
YR 2019
UL http://biorxiv.org/content/early/2019/01/26/273482.abstract
AB Despite the widespread use of transcranial magnetic stimulation (TMS), knowledge of its neurophysiological mode of action is still incomplete. Recently, TMS has been proposed to synchronise neural oscillators, and to thereby increase the detectability of corresponding oscillations at the population level. As oscillations in the human brain are known to interact within nested hierarchies via phase-amplitude coupling, TMS might also be able to increase the macroscopic detectability of such coupling. In a concurrent TMS-electroencephalography study, we therefore examined the technique’s influence on theta-gamma, alpha-gamma and beta-gamma phase-amplitude coupling by delivering single-pulse TMS (sTMS) and repetitive TMS (rTMS) over the left motor cortex and right visual cortex of healthy participants. The rTMS pulse trains were of 5 Hz, 11 Hz and 23 Hz for the three coupling variations, respectively. Relative to sham stimulation, all conditions showed transient but significant increases in phase-amplitude coupling at the stimulation site. In addition, we observed enhanced coupling over various other cortical sites, with a more extensive propagation during rTMS than during sTMS. By indicating that scalp-recorded phase-amplitude coupling can be effectively probed with TMS, these findings open the door to the technique’s application in manipulative dissections of such coupling during human cognition and behaviour in healthy and pathological conditions.