RT Journal Article
SR Electronic
T1 Evaluating spiny mice (<em>Acomys</em>) as a model for cardiac research
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.29.317388
DO 10.1101/2020.09.29.317388
A1 Kazuhiro Shindo
A1 Hsuan Peng
A1 Renée R. Donahue
A1 Brooke M. Ahern
A1 Bryana M. Levitan
A1 Jonathan Satin
A1 Ashley W. Seifert
A1 Ahmed Abdel-Latif
YR 2020
UL http://biorxiv.org/content/early/2020/10/01/2020.09.29.317388.abstract
AB Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and function. In this study, we characterized cardiac structure, anatomy, and in vivo function, as well as cardiomyocyte characteristics in Acomys compared to the most commonly used cardiac mouse model, the C57BL6 mouse strain (Mus). Our results demonstrate comparable cardiac anatomy, structure and function between the two rodent species, but reveal significant differences in their cardiomyocyte characteristics. These findings establish Acomys as a new mammalian model for cardiac research.Competing Interest StatementThe authors have declared no competing interest.