PT  - JOURNAL ARTICLE
AU  - Chen, Fei
AU  - El Naccache, Darine W.
AU  - Ponessa, John
AU  - Lemenze, Alexander
AU  - Espinosa, Vanessa
AU  - Wu, Wenhui
AU  - Lothstein, Katherine
AU  - Jin, Linhua
AU  - Rivera, Amariliz
AU  - Siracusa, Mark
AU  - Gause, William C.
TI  - Monocyte-derived alveolar macrophages mediate resistance to migrating helminths through depletion of arginine availability
AID  - 10.1101/2020.10.02.322388
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.10.02.322388
4099  - http://biorxiv.org/content/early/2020/10/02/2020.10.02.322388.short
4100  - http://biorxiv.org/content/early/2020/10/02/2020.10.02.322388.full
AB  - We examined the activation and effector functions of lung macrophages in mediating immunity against helminth parasites. Using fate mapping mice, we showed that monocytes recruited to the lung assume an alveolar macrophage phenotype and comprise as many as 10% of alveolar macrophages by 7 days after inoculation. Monocyte-derived alveolar macrophages assume distinct transcriptional and metabolic profiles that include high levels of arginase expression and preferentially mediate helminth damage, both of which are dependent on neutrophil help. In further studies, arginase was shown to mediate helminth killing through localized depletion of arginine.Competing Interest StatementThe authors have declared no competing interest.