RT Journal Article
SR Electronic
T1 Monocyte-derived alveolar macrophages mediate resistance to migrating helminths through depletion of arginine availability
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.02.322388
DO 10.1101/2020.10.02.322388
A1 Chen, Fei
A1 El Naccache, Darine W.
A1 Ponessa, John
A1 Lemenze, Alexander
A1 Espinosa, Vanessa
A1 Wu, Wenhui
A1 Lothstein, Katherine
A1 Jin, Linhua
A1 Rivera, Amariliz
A1 Siracusa, Mark
A1 Gause, William C.
YR 2020
UL http://biorxiv.org/content/early/2020/10/02/2020.10.02.322388.abstract
AB We examined the activation and effector functions of lung macrophages in mediating immunity against helminth parasites. Using fate mapping mice, we showed that monocytes recruited to the lung assume an alveolar macrophage phenotype and comprise as many as 10% of alveolar macrophages by 7 days after inoculation. Monocyte-derived alveolar macrophages assume distinct transcriptional and metabolic profiles that include high levels of arginase expression and preferentially mediate helminth damage, both of which are dependent on neutrophil help. In further studies, arginase was shown to mediate helminth killing through localized depletion of arginine.Competing Interest StatementThe authors have declared no competing interest.