PT - JOURNAL ARTICLE AU - Tristan Croll AU - Kay Diederichs AU - Florens Fischer AU - Cameron Fyfe AU - Yunyun Gao AU - Sam Horrell AU - Agnel Praveen Joseph AU - Luise Kandler AU - Oliver Kippes AU - Ferdinand Kirsten AU - Konstantin Müller AU - Kristoper Nolte AU - Alex Payne AU - Matthew G. Reeves AU - Jane Richardson AU - Gianluca Santoni AU - Sabrina Stäb AU - Dale Tronrud AU - Christopher Williams AU - Andrea Thorn TI - Making the invisible enemy visible AID - 10.1101/2020.10.07.307546 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.10.07.307546 4099 - http://biorxiv.org/content/early/2020/10/07/2020.10.07.307546.short 4100 - http://biorxiv.org/content/early/2020/10/07/2020.10.07.307546.full AB - During the COVID-19 pandemic, structural biologists have rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genome in order to understand the viral life cycle and enable structure-based drug design. In addition to the 200 structures from SARS-CoV previously solved, 367 structures covering 16 of the viral proteins have been released in the span of only 6 months.These structural models serve as basis for research worldwide to understand how the virus hijacks human cells, for structure-based drug design and to aid in the development of vaccines. However, errors often occur in even the most careful structure determination - and are even more common among these structures, which were solved under immense pressure.From the beginning of the pandemic, the Coronavirus Structural Taskforce has categorized, evaluated and reviewed all of these experimental protein structures in order to help downstream users and original authors. Our website also offers improved models for many key structures, which have been used by Folding@Home, OpenPandemics, the EU JEDI COVID-19 challenge, and others. Here, we describe our work for the first time, give an overview of common problems, and describe a few of these structures that have since acquired better versions in the worldwide Protein Data Bank, either from new data or as depositor re-versions using our suggested changes.Competing Interest StatementThe authors have declared no competing interest.