RT Journal Article
SR Electronic
T1 CoRa –A general approach for quantifying biological feedback control
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.09.334078
DO 10.1101/2020.10.09.334078
A1 Gómez-Schiavon, Mariana
A1 El-Samad, Hana
YR 2020
UL http://biorxiv.org/content/early/2020/10/10/2020.10.09.334078.abstract
AB Feedback control is a fundamental underpinning of life, underlying homeostasis of biological processes at every scale of organization, from cells to ecosystems. The ability to evaluate the contribution and limitations of feedback control mechanisms operating in cells is a critical step for understanding and ultimately designing feedback control systems with biological molecules. Here, we introduce CoRa –or Control Ratio–, a general framework that quantifies the contribution of a biological feedback control mechanism to adaptation using a mathematically controlled comparison to an identical system that does not contain the feedback. CoRa provides a simple and intuitive metric with broad applicability to biological feedback systems.Competing Interest StatementThe authors have declared no competing interest.