RT Journal Article
SR Electronic
T1 Innate Behavior Sequence Progression by Peptide-Mediated Interorgan Crosstalk
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.10.334540
DO 10.1101/2020.10.10.334540
A1 Heredia, Fabiana
A1 Volonté, Yanel
A1 Pereirinha, Joana
A1 Fernandez-Acosta, Magdalena
A1 Casimiro, Andreia P.
A1 Belém, Cláudia G.
A1 Viegas, Filipe
A1 Tanaka, Kohtaro
A1 Arana, Maite
A1 Cardoso, Gisele A.
A1 Macedo, André
A1 Kotowicz, Malwina
A1 Prado Spalm, Facundo H.
A1 Dibo, Marcos J.
A1 Monfardini, Raquel D.
A1 Torres, Tatiana T.
A1 Mendes, César S.
A1 Garelli, Andres
A1 Gontijo, Alisson M.
YR 2020
UL http://biorxiv.org/content/early/2020/10/10/2020.10.10.334540.abstract
AB Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of fly larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.Competing Interest StatementThe authors have declared no competing interest.