PT  - JOURNAL ARTICLE
AU  - Chao Ning
AU  - Daniel Fernandes
AU  - Piya Changmai
AU  - Olga Flegontova
AU  - Eren Yüncü
AU  - Robert Maier
AU  - N. Ezgi Altınışık
AU  - Alexei S. Kassian
AU  - Johannes Krause
AU  - Carles Lalueza-Fox
AU  - Andrea Manica
AU  - Ben A. Potter
AU  - Martine Robbeets
AU  - Kendra Sirak
AU  - Veronika Siska
AU  - Edward J. Vajda
AU  - Leonid A. Vyazov
AU  - Ke Wang
AU  - Lixin Wang
AU  - Xiyan Wu
AU  - Xiaoming Xiao
AU  - Fan Zhang
AU  - David Reich
AU  - Stephan Schiffels
AU  - Ron Pinhasi
AU  - Yinqiu Cui
AU  - Pavel Flegontov
TI  - The genomic formation of First American ancestors in East and Northeast Asia
AID  - 10.1101/2020.10.12.336628
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.10.12.336628
4099  - http://biorxiv.org/content/early/2020/10/12/2020.10.12.336628.short
4100  - http://biorxiv.org/content/early/2020/10/12/2020.10.12.336628.full
AB  - Upward Sun River 1, an individual from a unique burial of the Denali tradition in Alaska (11500 calBP), is considered a type representative of Ancient Beringians who split from other First Americans 22000–18000 calBP in Beringia. Using a new admixture graph model-comparison approach resistant to overfitting, we show that Ancient Beringians do not form the deepest American lineage, but instead harbor ancestry from a lineage more closely related to northern North Americans than to southern North Americans. Ancient Beringians also harbor substantial admixture from a lineage that did not contribute to other Native Americans: Amur River Basin populations represented by a newly reported site in northeastern China. Relying on these results, we propose a new model for the genomic formation of First American ancestors in Asia.One Sentence Summary Ancient Beringians do not form the deepest American lineage, but harbor admixture from Amur River Basin populations.Competing Interest StatementThe authors have declared no competing interest.