PT - JOURNAL ARTICLE AU - Aaron J. Wilk AU - Arjun Rustagi AU - Nancy Q. Zhao AU - Beth A. Martin AU - Angela J. Rogers AU - Catherine A. Blish TI - Additional analyses exploring the hypothesized transdifferentiation of plasmablasts to developing neutrophils in severe COVID-19 AID - 10.1101/2020.10.15.339473 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.10.15.339473 4099 - http://biorxiv.org/content/early/2020/10/16/2020.10.15.339473.short 4100 - http://biorxiv.org/content/early/2020/10/16/2020.10.15.339473.full AB - We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects of their criticism of our analysis to be problematic. Here we respond briefly to misunderstandings and inaccuracies in their commentary that may have led to misinformed interpretation of our results.Competing Interest StatementThe authors have declared no competing interest.