TY - JOUR T1 - SKiM - A generalized literature-based discovery system for uncovering novel biomedical knowledge from PubMed JF - bioRxiv DO - 10.1101/2020.10.16.343012 SP - 2020.10.16.343012 AU - Kalpana Raja AU - John Steill AU - Ian Ross AU - Lam C Tsoi AU - Finn Kuusisto AU - Zijian Ni AU - Miron Livny AU - James Thomson AU - Ron Stewart Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/10/17/2020.10.16.343012.abstract N2 - Literature-based discovery (LBD) uncovers undiscovered public knowledge by linking terms A to C via a B intermediate. Existing LBD systems are limited to process certain A, B, and C terms, and many are not maintained. We present SKiM (Serial KinderMiner), a generalized LBD system for processing any combination of A, Bs, and Cs. We evaluate SKiM via the rediscovery of discoveries by Don Swanson, who pioneered LBD. Using only literature from the 19th century up to a year before Swanson’s discoveries, SKiM uncovers all five discoveries. We apply SKiM to repurposing drugs for 26 conditions of high prevalence. Manual analysis confirmed 65 discoveries useful for four diseases from Swanson’s discoveries from one to 31 years prior to their first validation by clinical trials. SKiM predicts many new potential drug candidates representing prime targets for wet lab validation. SKiM can be applied to any biomedical inquiry sufficiently mentioned in the literature.Competing Interest StatementThe authors have declared no competing interest. ER -