RT Journal Article
SR Electronic
T1 Experience-dependent alteration of mnemonic representation in early visual cortex and intraparietal sulcus
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.20.347179
DO 10.1101/2020.10.20.347179
A1 Ke Jia
A1 Ya Li
A1 Mengyuan Gong
A1 Hui Huang
A1 Yonghui Wang
A1 Sheng Li
YR 2020
UL http://biorxiv.org/content/early/2020/10/21/2020.10.20.347179.abstract
AB The ability to discriminate between stimuli relies on a chain of neural operations associated with perception, memory and decision-making. Accumulating studies show learning-dependent plasticity in perception or decision-making, yet whether perceptual learning modifies mnemonic processing remains unclear. Here, we trained participants on an orientation discrimination task, while using fMRI and TMS to separately examine training-induced changes in working memory (WM) representation. Although fMRI decoding revealed orientation-specific neural patterns during delay period in early visual cortex (V1) before, but not after, training, neurodisruption of V1 during delay period led to behavioral deficit in both phases. In contrast, both fMRI decoding and disruptive effect of TMS showed that intraparietal sulcus (IPS) represent WM content after, but not before, training. These results suggest that sensory engagement for WM is relatively independent of training but the coding format may be altered, whereas the involvement of parietal area in WM depends on training.Competing Interest StatementThe authors have declared no competing interest.