RT Journal Article
SR Electronic
T1 Dysregulation of Pulmonary Responses in Severe COVID-19
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.23.353177
DO 10.1101/2020.10.23.353177
A1 Dandan Wu
A1 Xuexian O. Yang
YR 2020
UL http://biorxiv.org/content/early/2020/10/25/2020.10.23.353177.abstract
AB Patients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms and high mortality is associated with respiratory failure second to severe disease. The risk factors leading to severe disease remain unclear. Here, we reanalyzed a published single-cell RNA-Seq (scRNA-Seq) dataset and found that bronchoalveolar lavage fluid (BALF) of patients with severe disease compared to those with mild disease contained decreased TH17 type cells, decreased IFNA1 expressing cells with lower expression of toll-like receptor 7 (TLR7) and TLR8, increased IgA expressing B cells, and increased hyperactive epithelial cells (and/or macrophages) expressing matrix metalloproteinases (MMPs), Hyaluronan synthase 2 (HAS2), and Plasminogen activator inhibitor-1 (PAI-1), which may together contribute to the pulmonary pathology in severe COVID-19. We propose IFN-I (and TLR7/TLR8) and PAI-1 as potential biomarkers to predict the susceptibility to severe COVID19.Competing Interest StatementThe authors have declared no competing interest.