RT Journal Article
SR Electronic
T1 Comparison of the <em>in vitro</em>-efficacy of different mouthwash solutions targeting SARS-CoV-2 based on the European Standard EN 14476
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.25.354571
DO 10.1101/2020.10.25.354571
A1 Katrin Steinhauer
A1 Toni Luise Meister
A1 Daniel Todt
A1 Adalbert Krawczyk
A1 Lars Paßvogel
A1 Britta Becker
A1 Dajana Paulmann
A1 Birte Bischoff
A1 Stephanie Pfaender
A1 Florian H H Brill
A1 Eike Steinmann
YR 2020
UL http://biorxiv.org/content/early/2020/10/26/2020.10.25.354571.abstract
AB The SARS-Cov-2 pandemic is triggering a global health emergency alert, and recent research is indicating the relevance of aerosols in the spread of SARS-CoV-2. Thus, in this study antiseptic mouthwashes based on the actives chlorhexidine (CHX) and octenidine (OCT) were investigated regarding their efficacy against SARS-CoV-2 using EN 14476. Based on the requirement of EN 14476 (i.e. reduction of viral titer by ≥ 4 log 10), the OCT-based formulation was effective within only 15 sec against SARS-CoV-2, and thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of SARS-CoV-2 transmission by aerosols.Competing Interest StatementConflict of interest The authors KS and LP are employees of Schuelke &amp; Mayr GmbH, Norderstedt, Germany. Funding source This study was funded by Schuelke &amp; Mayr GmbH, Norderstedt, Germany.