RT Journal Article
SR Electronic
T1 <em>Pseudomonas aeruginosa</em> PA14 biofilms produce R-bodies, extendable protein polymers with roles in host colonization and virulence
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.26.356394
DO 10.1101/2020.10.26.356394
A1 Bryan Wang
A1 Yu-Cheng Lin
A1 Jeanyoung Jo
A1 Alexa Price-Whelan
A1 Shujuan Tao McDonald
A1 Lewis M. Brown
A1 Lars E.P. Dietrich
YR 2020
UL http://biorxiv.org/content/early/2020/10/27/2020.10.26.356394.abstract
AB reb genes code for R-bodies: large, extendable polymers that are known for their roles in obligate endosymbioses. In the non-endosymbiotic pathogen Pseudomonas aeruginosa, reb homologues are part of a cluster found in virulent strains. Here, we demonstrate that R-bodies are produced in abundance by P. aeruginosa PA14 subpopulations during biofilm growth, identify regulators of reb gene expression, and show that reb genes are required for full colonization and virulence in host models.Competing Interest StatementThe authors have declared no competing interest.