RT Journal Article
SR Electronic
T1 Interpreting the dynamic pathogenesis of Parkinson’s disease by longitudinal blood transcriptome analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.26.356204
DO 10.1101/2020.10.26.356204
A1 Xue, Gang
A1 Wang, Gang
A1 Shi, Qianqian
A1 Wang, Hui
A1 Lv, Bo-Min
A1 Gao, Min
A1 Niu, Xiaohui
A1 Zhang, Hong-Yu
YR 2020
UL http://biorxiv.org/content/early/2020/10/28/2020.10.26.356204.abstract
AB Achieving an improved understanding of the temporal sequence of factors involved in Parkinson’s disease (PD) pathogenesis may accelerate drug discovery. In this study, we performed a longitudinal transcriptome analysis to identify associated genes underlying the pathogenesis of PD at three temporal phases. We firstly found that multiple initiator genes, which are related to processes of olfactory transduction and stem cell pluripotency, indicate PD risk to those subjects at the prodromal phase. And many facilitator genes involved in calcium signaling and stem cell pluripotency contribute to PD onset. We next identified 325 aggravator genes whose expression could lead to disease progression through damage to dopaminergic synapses and ferroptosis via an integrative analysis with DNA methylation. Last, we made a systematic comparison of gene expression patterns across PD development and accordingly provided candidate drugs at different phases in an attempt to prevent the neurodegeneration process.Competing Interest StatementThe authors have declared no competing interest.