RT Journal Article
SR Electronic
T1 A GO catalogue of human DNA-binding transcription factors
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.10.28.359232
DO 10.1101/2020.10.28.359232
A1 Ruth C. Lovering
A1 Pascale Gaudet
A1 Marcio L. Acencio
A1 Alex Ignatchenko
A1 Arttu Jolma
A1 Oriol Fornes
A1 Martin Kuiper
A1 Ivan V. Kulakovskiy
A1 Astrid Lægreid
A1 Maria J. Martin
A1 Colin Logie
YR 2020
UL http://biorxiv.org/content/early/2020/10/28/2020.10.28.359232.abstract
AB DNA-binding transcription factors recognise genomic addresses, specific sequence motifs in gene regulatory regions, to control gene transcription. A complete and reliable catalogue of all DNA-binding transcription factors is key to investigating the delicate balance of gene regulation in response to environmental and developmental stimuli. The need for such a catalogue of proteins is demonstrated by the many lists of DNA-binding transcription factors that have been produced over the past decade.The COST Action Gene Regulation Ensemble Effort for the Knowledge Commons (GREEKC) Consortium brought together experts in the field of transcription with the aim of providing high quality and interoperable gene regulatory data. The Gene Ontology (GO) Consortium provides strict definitions for gene product function, including factors that regulate transcription. The collaboration between the GREEKC and GO Consortia has enabled the application of those definitions to produce a new curated catalogue of human DNA-binding transcription factors, that can be accessed at https://www.ebi.ac.uk/QuickGO/targetset/dbTF.In addition, this curation effort has led to the GO annotation of almost sixty thousand DNA-binding transcription factors in over a hundred species. Thus, this work will aid researchers investigating the regulation of transcription in both biomedical and basic science.Competing Interest StatementThe authors have declared no competing interest.coTFtranscription coregulatordbTFDNA-binding transcription factors that bind to a specific-sequence (or motif) in double-stranded DNA.GOGene OntologyGTFgeneral (or basal) transcription factor