RT Journal Article
SR Electronic
T1 Reduced Plasma Ascorbic Acid Levels in Recipients of Myeloablative Conditioning & Hematopoietic Cell Transplantation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 539007
DO 10.1101/539007
A1 Mahmood Rasheed
A1 Gary Simmons
A1 Bernard Fisher
A1 Kevin Leslie
A1 Jason Reed
A1 Catherine Roberts
A1 Ramesh Natarajan
A1 Alpha Fowler
A1 Amir Toor
YR 2019
UL http://biorxiv.org/content/early/2019/02/03/539007.abstract
AB Hematopoietic cell transplantation (HCT) conditioned using myeloablative conditioning (MAC) is complicated by end organ injury due to endothelial dysfunction and graft versus host disease. Mucositis and oxidant injury results in micronutrient deficiency. Ascorbic acid (AA) levels were measured in 15 patients undergoing HCT conditioned with MAC (11 allogeneic and 4 autologous HCT). Ascorbate levels declined post conditioning to 27.3 (±14.1) by day 0 (p <0.05 compared with baseline), reaching a nadir level of 21.5 (±13.8) on day 14 (p <0.05) post-transplant. Patients undergoing allogeneic HCT continued to have low AA levels to day 60 post transplant, whereas recipients of autologous HCT recovered plasma AA levels to normal. The role of AA in maintaining endothelial function and hematopoietic as well as T cell recovery is provided, developing the rationale for repletion of vitamin C following HCT.