PT  - JOURNAL ARTICLE
AU  - Sorena Rahmanian
AU  - Rabi Murad
AU  - Alessandra Breschi
AU  - Weihua Zeng
AU  - Mark Mackiewicz
AU  - Brian Williams
AU  - Carrie Davis
AU  - Brian Roberts
AU  - Sarah Meadows
AU  - Dianna Moore
AU  - Diane Trout
AU  - Chris Zaleski
AU  - Alex Dobin
AU  - Lei-Hoon Sei
AU  - Jorg Drenkow
AU  - Alex Scavelli
AU  - Thomas Gingeras
AU  - Barbara Wold
AU  - Richard M. Myers
AU  - Roderic Guigó
AU  - Ali Mortazavi
TI  - Dynamics of microRNA expression during mouse prenatal development
AID  - 10.1101/492918
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 492918
4099  - http://biorxiv.org/content/early/2019/02/04/492918.short
4100  - http://biorxiv.org/content/early/2019/02/04/492918.full
AB  - MicroRNAs (miRNAs) play a critical role as post-transcriptional regulators of gene expression. The ENCODE project profiled the expression of miRNAs in a comprehensive set of tissues during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct tissue and developmental stage specific miRNA expression clusters, with an overall pattern of increasing tissue specific expression as development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by tissue types rather than by species. An analysis of messenger RNA gene expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the tissue where these microRNAs are expressed during embryonic development. Our results provide the most comprehensive timecourse of miRNA expression as an integrated part of the ENCODE reference dataset for mouse embryonic development.