RT Journal Article
SR Electronic
T1 Low-dimensional Dynamics of Two Coupled Biological Oscillators
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 541128
DO 10.1101/541128
A1 Colas Droin
A1 Eric R Paquet
A1 Felix Naef
YR 2019
UL http://biorxiv.org/content/early/2019/02/05/541128.abstract
AB The circadian clock and the cell cycle are two biological oscillatory processes that coexist within individual cells. These two oscillators were found to interact, which can lead to their synchronization. Here, we develop a method to infer their coupling and non-linear dynamics from thousands of mouse and human single-cell microscopy traces. This coupling predicts multiple phase-locked states showing different degrees of robustness against molecular fluctuations inherent to cellular scale biological oscillators. Moreover, the phase–locked states were temperature-independent and evolutionarily conserved from mouse to human, hinting at a common underlying dynamical mechanism. Finally, we detected a signature of the coupled dynamics in a physiological context, where tissues with different proliferation states exhibited shifted circadian clock phases.