TY - JOUR T1 - Domain-relevant auditory expertise modulates the additivity of neural mismatch responses in humans JF - bioRxiv DO - 10.1101/541037 SP - 541037 AU - Niels Chr. Hansen AU - Andreas Højlund AU - Cecilie Møller AU - Marcus Pearce AU - Peter Vuust Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/02/05/541037.abstract N2 - It is unknown whether domain-relevant expertise is associated with more independent or more dependent predictive processing of acoustic features. Here, mismatch negativity (MMNm) was recorded with magnetoencephalography (MEG) from 25 musicians and 25 non-musicians, exposed to complex musical multi-feature and simple oddball control paradigms. Deviants differed in frequency (F), intensity (I), perceived location (L), or any combination of these (FI, IL, LF, FIL). Neural processing overlap was assessed through MMNm additivity by comparing double- and triple-deviant MMNms (“empirical”) to summed constituent single-deviant MMNms (“modelled”). Significantly greater subadditivity was present in musicians compared to non-musicians, specifically for frequency-related deviants in complex contexts. Despite using identical sounds, expertise effects were absent from the simple paradigm. This novel finding supports the dependent processing hypothesis whereby experts recruit overlapping neural resources facilitating more integrative representations of domain-relevant stimuli. Such specialized predictive processing may enable experts such as musicians to capitalise on complex acoustic cues. ER -