PT  - JOURNAL ARTICLE
AU  - Ismael Fernández-Hernández
AU  - Eric Hu
AU  - Michael A. Bonaguidi
TI  - Olfactory neuron turnover in adult <em>Drosophila</em>
AID  - 10.1101/2020.11.08.371096
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.11.08.371096
4099  - http://biorxiv.org/content/early/2020/11/09/2020.11.08.371096.short
4100  - http://biorxiv.org/content/early/2020/11/09/2020.11.08.371096.full
AB  - Sustained neurogenesis occurs in the olfactory epithelium of several species, including humans, to support olfactory function throughout life. We recently developed a modified lineage tracing method to identify adult neurogenesis in Drosophila. By applying this technique, here we report on the continuous generation of Olfactory Sensory Neurons (OSN) in the antennae of adult Drosophila. New neurons develop sensory dendrites and project axons targeting diverse glomeruli of the antennal lobes in the brain. Furthermore, we identified sustained apoptosis of OSN in the antennae of adult flies, revealing unexpected turnover in the adult olfactory system. Our results substantiate Drosophila as a compelling platform to expedite research about mechanisms and compounds promoting neuronal regeneration, circuit remodeling and its contribution to behavior in the adult.Competing Interest StatementThe authors have declared no competing interest.