RT Journal Article SR Electronic T1 Drosophila p38 MAPK Interacts with BAG-3/starvin to Regulate Age-dependent Protein Homeostasis JF bioRxiv FD Cold Spring Harbor Laboratory SP 552729 DO 10.1101/552729 A1 Sarah M. Ryan A1 Michael Almassey A1 Amelia M. Burch A1 Gia Ngo A1 Julia M. Martin A1 David Myers A1 Devin Compton A1 Scott Barbee A1 Nathan T. Mortimer A1 Subhabrata Sanyal A1 Alysia D. Vrailas-Mortimer YR 2020 UL http://biorxiv.org/content/early/2020/11/10/552729.abstract AB As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age-related diseases. This accumulation of protein aggregates is partially attributed to a failure to maintain protein homeostasis. A variety of genetic factors have been linked to longevity, but how these factors also contribute to protein homeostasis is not completely understood. In order to understand the relationship between aging and protein aggregation, we tested how a gene that regulates lifespan and age-dependent locomotor behaviors, p38 MAPK (p38Kb), influences protein homeostasis as an organism ages. We find that p38Kb regulates age-dependent protein aggregation through an interaction with the Chaperone-Assisted Selective Autophagy complex. Furthermore, we have identified Lamin as an age-dependent target of p38Kb and the Chaperone-Assisted Selective Autophagy complex.Competing Interest StatementThe authors have declared no competing interest.