TY - JOUR T1 - Engineered Prime Editors with PAM flexibility JF - bioRxiv DO - 10.1101/2020.11.10.377580 SP - 2020.11.10.377580 AU - Jiyeon Kweon AU - Jung-Ki Yoon AU - An-Hee Jang AU - Ha Rim Shin AU - Ji-Eun See AU - Gayoung Jang AU - Jong-Il Kim AU - Yongsub Kim Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/11/11/2020.11.10.377580.abstract N2 - Although prime editors are a powerful tool for genome editing, which can generate various types of mutations such as nucleotide substitutions, insertions, and deletions in the genome without double-strand breaks or donor DNA, the conventional prime editors are still limited to its target scopes because of the PAM preference of the spCas9 protein. Here, we described the engineered prime editors to expand the range of their target sites using various PAM-flexible Cas9 variants.Competing Interest StatementThe authors have declared no competing interest. ER -