RT Journal Article SR Electronic T1 Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.11.11.365387 DO 10.1101/2020.11.11.365387 A1 Francesco Marabita A1 Tojo James A1 Anu Karhu A1 Robert Mills A1 Teemu Perheentupa A1 Hans Stenlund A1 Fredrik Boulund A1 Cecilia Hellström A1 Maja Neiman A1 Heidi Virtanen A1 Kaisa Kettunen A1 Hannele Laivuori A1 Pyry Helkkula A1 Myles Byrne A1 Harri Honko A1 Antti Kallonen A1 Miikka Ermes A1 Heidi Similä A1 Mikko Lindholm A1 Elisabeth Widen A1 Samuli Ripatti A1 Maritta Perälä-Heape A1 Lars Engstrand A1 Peter Nilsson A1 Thomas Moritz A1 Timo Miettinen A1 Riitta Sallinen A1 Olli Kallioniemi YR 2020 UL http://biorxiv.org/content/early/2020/11/12/2020.11.11.365387.abstract AB We collected clinical measurements, health surveys and multiomics profiles (genomics, proteomics, autoantibodies, metabolomics and gut microbiome) from 96 individuals over 16 months, along with daily activity and sleep monitoring. Between- and within-individual variability was analysed as the participants underwent data-driven health coaching. Multiomics factor analysis resulted in an unsupervised integrated view of the data, with individual factors explaining distinct aspects of variability in human health and lifestyle, such as obesity, diabetes, liver function, cardiovascular disease, inflammation, immunity, hormonal function, exercise and diet. The data revealed both known and new associations between molecular pathways, risk factors, behaviour and lifestyle aspects. Data-driven analysis of multidimensional molecular and digital signatures of participants over time enabled deep understanding of biological variability between people as well as the systemic effects of lifestyle changes. Our study facilitates a detailed evaluation of aspects impacting on health and underlines the importance of personal molecular signatures.Competing Interest Statementto be completed in updated version