RT Journal Article
SR Electronic
T1 ICGenealogy: Mapping the Function of Neuronal Ion Channels in Model and Experiment
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 058685
DO 10.1101/058685
A1 William F Podlaski
A1 Alexander Seeholzer
A1 Lukas N Groschner
A1 Gero Miesenböck
A1 Rajnish Ranjan
A1 Tim P Vogels
YR 2016
UL http://biorxiv.org/content/early/2016/06/16/058685.abstract
AB Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretability of simulations. However, the number of published models, and the lack of standardization, make the comparison of models with one another and with experimental data difficult. Here, we present a framework for the automated large-scale classification of ion channel models. Using annotated metadata and model responses to a set of voltage-clamp protocols, we assigned 2378 models of voltage- and calcium-gated ion channels coded in NEURON to 211 clusters. The IonChannelGenealogy web interface provides an interactive resource for the categorization of new and existing models and experimental recordings. It enables quantitative comparisons of simulated and/or measured ion channel kinetics, and facilitates field-wide standardization of experimentally-constrained modeling.