RT Journal Article
SR Electronic
T1 The Surprising Role of the Default Mode Network
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.05.18.101758
DO 10.1101/2020.05.18.101758
A1 T. Brandman
A1 R. Malach
A1 E. Simony.
YR 2020
UL http://biorxiv.org/content/early/2020/11/15/2020.05.18.101758.abstract
AB The default mode network (DMN) is a group of high-order brain regions recently implicated in processing external naturalistic events, yet it remains unclear what cognitive function it serves. Here we identified the cognitive states predictive of DMN fMRI coactivation. Particularly, we developed a state-fluctuation pattern analysis, matching network coactivations across a short movie with retrospective behavioral sampling of movie events. Network coactivation was selectively correlated with the state of surprise across movie events, compared to all other cognitive states (e.g. emotion, vividness). The effect was exhibited in the DMN, but not dorsal attention or visual networks. Furthermore, surprise was found to mediate DMN coactivations with hippocampus and nucleus accumbens. These unexpected findings point to the DMN as a major hub in high-level prediction-error representations.Competing Interest StatementThe authors have declared no competing interest.