RT Journal Article
SR Electronic
T1 Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 422782
DO 10.1101/422782
A1 Catherine John
A1 Nicola F Reeve
A1 Robert C Free
A1 Alexander T Williams
A1 Aliki-Eleni Farmaki
A1 Jane Bethea
A1 Linda M Barton
A1 Nick Shrine
A1 Chiara Batini
A1 Richard Packer
A1 Sarah Terry
A1 Beverley Hargadon
A1 Qingning Wang
A1 Carl A Melbourne
A1 Emma L Adams
A1 Catherine E Bee
A1 Kyla Harrington
A1 José Miola
A1 Nigel J Brunskill
A1 Christopher E Brightling
A1 Julian Barwell
A1 Susan E Wallace
A1 Ron Hsu
A1 David J Shepherd
A1 Edward J Hollox
A1 Louise V Wain
A1 Martin D Tobin
YR 2019
UL http://biorxiv.org/content/early/2019/02/07/422782.abstract
AB EXCEED is a longitudinal population-based cohort which facilitates investigation of genetic, environmental and lifestyle-related determinants of a broad range of diseases and of multiple morbidity through data collected at baseline and via electronic healthcare record linkage. Recruitment has taken place in Leicester, Leicestershire and Rutland since 2013 and is ongoing, with 10 156 participants aged 30-69 to date. The population of Leicester is diverse and additional recruitment from the local South Asian community is ongoing. Participants have consented to follow-up for up to 25 years through electronic health records (EHR). Data available includes baseline demographics, anthropometry, spirometry, lifestyle factors (smoking and alcohol use) and longitudinal health information from primary care records, with additional linkage to other EHR datasets planned. Patients have consented to be contacted for recall-by-genotype and recall-by-phenotype sub-studies, providing an important resource for precision medicine research. We welcome requests for collaboration and data access by contacting the study management team via exceed{at}le.ac.uk.