TY - JOUR T1 - Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury JF - bioRxiv DO - 10.1101/869826 SP - 869826 AU - Meredith A. Redd AU - Sarah E. Scheuer AU - Natalie J. Saez AU - Ling Gao AU - Mark Hicks AU - Jeanette E. Villanueva AU - Melissa E. Reichelt AU - Jason N. Peart AU - Louise E. See Hoe AU - Han S. Chiu AU - Xiaoli Chen AU - Yuliangzi Sun AU - Jacky Y. Suen AU - Robert J Hatch AU - Ben Rollo AU - Mubarak A.H. Alzubaidi AU - Snezana Maljevic AU - Greg A. Quaife-Ryan AU - Walter G. Thomas AU - James E. Hudson AU - Enzo R. Porrello AU - Gabriel Cuellar-Partida AU - John F. Fraser AU - Steven Petrou AU - Glenn F. King AU - Peter S. Macdonald AU - Nathan J. Palpant Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/11/17/869826.abstract N2 - The proton-gated acid-sensing ion channel 1a (ASIC1a) is implicated in the injury response to cerebral ischemia but little is known about its role in cardiac ischemia. We provide genetic evidence that ASIC1a is involved in myocardial ischemia-reperfusion injury (IRI) and show that pharmacological inhibition of ASIC1a yields robust cardioprotection in rodent and human models of cardiac ischemia, resulting in improved post-IRI cardiac viability and function. Consistent with a key role for ASIC1a in cardiac ischemia, we show that polymorphisms in the ASIC1 genetic locus are strongly associated with myocardial infarction. Collectively, our data provide compelling evidence that ASIC1a is a key target for cardioprotective drugs to reduce the burden of disease associated with myocardial ischemia.Competing Interest StatementThe authors have declared no competing interest. ER -