PT  - JOURNAL ARTICLE
AU  - Evelina Statkute
AU  - Anzelika Rubina
AU  - Valerie B O’Donnell
AU  - David W. Thomas
AU  - Richard J. Stanton
TI  - Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro
AID  - 10.1101/2020.11.13.381079
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.11.13.381079
4099  - http://biorxiv.org/content/early/2020/11/18/2020.11.13.381079.short
4100  - http://biorxiv.org/content/early/2020/11/18/2020.11.13.381079.full
AB  - The ability of widely-available mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting a 5-log10 reduction in infectivity, under conditions mimicking the naso/oropharynx. During a 30 second exposure, two rinses containing cetylpyridinium-chloride and a third with ethanol/ethyl lauroyl arginate eliminated live virus to EN14476 standards (>4-log10 reduction), while others with ethanol/essential oils and povidone-iodine (PVP-I) eliminated virus by 2-3-log10. Chlorhexidine or ethanol alone displayed little or no ability to inactivate virus. Studies are warranted to determine whether these formulations can inactivate virus in the human oropharynx in vivo, and whether this might impact transmission risk.Competing Interest StatementThe authors have declared no competing interest.