RT Journal Article
SR Electronic
T1 Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.11.13.381079
DO 10.1101/2020.11.13.381079
A1 Statkute, Evelina
A1 Rubina, Anzelika
A1 O’Donnell, Valerie B
A1 Thomas, David W.
A1 Stanton, Richard J.
YR 2020
UL http://biorxiv.org/content/early/2020/11/18/2020.11.13.381079.abstract
AB The ability of widely-available mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting a 5-log10 reduction in infectivity, under conditions mimicking the naso/oropharynx. During a 30 second exposure, two rinses containing cetylpyridinium-chloride and a third with ethanol/ethyl lauroyl arginate eliminated live virus to EN14476 standards (>4-log10 reduction), while others with ethanol/essential oils and povidone-iodine (PVP-I) eliminated virus by 2-3-log10. Chlorhexidine or ethanol alone displayed little or no ability to inactivate virus. Studies are warranted to determine whether these formulations can inactivate virus in the human oropharynx in vivo, and whether this might impact transmission risk.Competing Interest StatementThe authors have declared no competing interest.