RT Journal Article
SR Electronic
T1 Local Targeted Memory Reactivation in Human Sleep
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 539114
DO 10.1101/539114
A1 Ella Bar
A1 Anat Arzi
A1 Ofer Perl
A1 Ethan Livne
A1 Noam Sobel
A1 Yadin Dudai
A1 Yuval Nir
YR 2019
UL http://biorxiv.org/content/early/2019/02/07/539114.abstract
AB Memory consolidation can be promoted via Targeted Memory Reactivation (TMR) that re-presents training cues or context during sleep. Whether TMR acts locally or globally on cortical sleep oscillations remains unknown. Here we exploit the unique functional neuroanatomy of olfaction with its ipsilateral stimulus processing to perform local TMR in one brain hemisphere. Participants learned associations between words and locations in left or right visual fields with contextual odor throughout. During post-learning naps, odors were presented to one nostril throughout NREM sleep. We found improved memory for specific words processed in the cued hemisphere (ipsilateral to stimulated nostril). Unilateral odor cues locally modulated slow wave activity (SWA) such that regional SWA increase in the cued hemisphere negatively correlated with select memories for cued words. Moreover, local TMR improved slow wave-spindle coupling specifically in the cued hemisphere. Thus, TMR in human sleep transcends global action by selectively promoting specific memories associated with local sleep oscillations.