PT  - JOURNAL ARTICLE
AU  - Hari Teja Kalidindi
AU  - Kevin P. Cross
AU  - Timothy P. Lillicrap
AU  - Mohsen Omrani
AU  - Egidio Falotico
AU  - Philip N. Sabes
AU  - Stephen H. Scott
TI  - Rotational dynamics in motor cortex are consistent with a feedback controller
AID  - 10.1101/2020.11.17.387043
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.11.17.387043
4099  - http://biorxiv.org/content/early/2020/11/20/2020.11.17.387043.short
4100  - http://biorxiv.org/content/early/2020/11/20/2020.11.17.387043.full
AB  - Recent studies hypothesize that motor cortical (MC) dynamics are generated largely through its recurrent connections based on observations that MC activity exhibits rotational structure. However, behavioural and neurophysiological studies suggest that MC behaves like a feedback controller where continuous sensory feedback and interactions with other brain areas contribute substantially to MC processing. We investigated these apparently conflicting theories by building recurrent neural networks that controlled a model arm and received sensory feedback about the limb. Networks were trained to counteract perturbations to the limb and to reach towards spatial targets. Network activities and sensory feedback signals to the network exhibited rotational structure even when the recurrent connections were removed. Furthermore, neural recordings in monkeys performing similar tasks also exhibited rotational structure not only in MC but also in somatosensory cortex. Our results argue that rotational structure may reflect dynamics throughout voluntary motor circuits involved in online control of motor actions.Neural networks with sensory feedback generate rotational dynamics during simulated posture and reaching tasksRotational dynamics are observed even without recurrent connections in the networkSimilar dynamics are observed not only in motor cortex, but also in somatosensory cortex of non-huma n primates as well as sensory feedback signalsResults highlight rotational dynamics may reflect internal dynamics, external inputs or any combination of the two.Competing Interest StatementSHS is co-founder and CSO of Kinarm which commercializes the robotic technology used in the present study.